First Time User? Enroll now.
*Vaccine availability and appointments* | Additional COVID-19 resources.
Please be aware that mask-wearing is required at all UNC Health facilities.
Home > Health Library > Vitamin B12 Deficiency Anemia
Having vitamin B12 deficiency means that your body does not have enough of this vitamin. You need B12 to make red blood cells, which carry oxygen through your body. Not having enough B12 can lead to anemia, which means your body does not have enough red blood cells to do the job. This can make you feel weak and tired. Vitamin B12 deficiency can cause damage to your nerves and can affect memory and thinking.
Most people get more than enough B12 from eating meat, eggs, milk, and cheese. Normally, the vitamin is absorbed by your digestive system—your stomach and intestines. Vitamin B12 deficiency anemia usually happens when the digestive system is not able to absorb the vitamin. This can happen if:
This anemia can also happen if you don't eat enough foods with B12, but this is rare. People who eat a vegan diet and older adults who don't eat a variety of foods may need to take a daily vitamin pill to get enough B12. Other causes include drinking alcohol and taking some prescription and nonprescription medicines.
The amount of vitamin B12 you need each day depends on your age. footnote 1
If your vitamin B12 deficiency is mild, you may not have symptoms or you may not notice them. Some people may think the symptoms are just the result of growing older. As the anemia gets worse, you may:
If the level of vitamin B12 stays low for a long time, it can damage your nerve cells. If this happens, you may have:
Your doctor will examine you and ask questions about your past health and how you are feeling now. You will also have blood tests to check the number of red blood cells and to see if your body has enough vitamin B12.
The level of folate, another B vitamin, will be checked too. Some people whose vitamin B12 levels are too low also have low levels of folate. The two problems can cause similar symptoms. But they are treated differently.
Vitamin B12 deficiency anemia is treated with supplements of vitamin B12. Taking supplements brings your level of vitamin B12 back to normal, so you do not have symptoms. To keep your level of vitamin B12 normal, you will probably need to take supplements for the rest of your life. If you stop taking them, you'll get anemia again.
Your vitamin B12 supplements might be pills or shots. If you use shots, you can learn to give them to yourself at home. For many people, pills work just as well as shots. They also cost less and are easier to take. If you have been getting shots, ask your doctor if you can switch to pills. Another form of treatment is a vitamin B12 nasal spray (such as Nascobal).
You can take steps at home to improve your health by eating a varied diet that includes meat, milk, cheese, and eggs, which are good sources of vitamin B12. Also, eat plenty of foods that contain folate (or folic acid), another type of B vitamin. These include leafy green vegetables, citrus fruits, and breads and cereals that are fortified with folic acid.
Most people who eat animal products like milk, cheese, and eggs will not get this B12 deficiency anemia. People who follow a vegan diet can prevent it by taking a daily vitamin pill or by eating foods that have been fortified with B12.
Babies born to women who eat a vegan diet should be checked by a doctor to see whether they need extra vitamin B12.
If you have pernicious anemia or another reason you cannot absorb enough vitamin B12, your doctor will give you vitamin B12 shots or pills to prevent deficiency.
Vitamin B12 is found in foods from animals, such as meat, seafood, milk products, poultry, and eggs. It is not in foods from plants unless it has been added to the food (fortified). Some foods, like cereals, are fortified with vitamin B12.
Supplements containing only B12, or B12 along with other B vitamins and/or folic acid, are readily available. Also, B12 is usually in multivitamins. Check the label to find out how much B12 is in a supplement.
B12 amount (micrograms)
Cereal fortified with 100% daily value for B12
Nonfat plain yogurt
Food and Nutrition Board, Institute of Medicine (2011). Dietary reference intakes (DRIs): Recommended dietary allowances and adequate intakes, vitamins. Available online: http://iom.edu/Activities/Nutrition/SummaryDRIs/~/media/Files/Activity%20Files/Nutrition/DRIs/New%20Material/2_%20RDA%20and%20AI%20Values_Vitamin%20and%20Elements.pdf.
Office of Dietary Supplements (2021). Vitamin B12 fact sheet for health professionals. National Institutes of Health. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/. Accessed July 29, 2021.
Current as of:
April 29, 2021
Author: Healthwise StaffMedical Review: E. Gregory Thompson MD - Internal MedicineMartin J. Gabica MD - Family MedicineAdam Husney MD - Family Medicine
Current as of: April 29, 2021
Author: Healthwise Staff
Medical Review:E. Gregory Thompson MD - Internal Medicine & Martin J. Gabica MD - Family Medicine & Adam Husney MD - Family Medicine
To learn more about Healthwise, visit Healthwise.org.
© 1995-2021 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Our interactive Decision Points guide you through making key health decisions by combining medical information with your personal information.
You'll find Decision Points to help you answer questions about:
Get started learning more about your health!
Our Interactive Tools can help you make smart decisions for a healthier life. You'll find personal calculators and tools for health and fitness, lifestyle checkups, and pregnancy.
Feeling under the weather?
Use our interactive symptom checker to evaluate your symptoms and determine appropriate action or treatment.